Dear Colleague, we are pleased to invite you to the Workshop DIFFRACTION 2010 International Workshop on Diffraction in High-Energy Physics [Web site: www.cs.infn.it/diff2010] which will take place at the Hotel Baia dei Turchi in Otranto (Lecce, Italy) in the period September 10 - 15, 2010. This Workshop is the sixth of the series "Diffraction", after Cetraro (Italy, 2000), Alushta (Ukraine, 2002), Cala Gonone (Italy, 2004), Milos (Greece, 2006) and La Londe-les-Maures (France, 2008). The Workshop is expected to cover a broad spectrum of topics, ranging from diffraction in high-energy physics to spin physics, strong interactions and related topics. The aim of this Workshop is to favour fruitful discussions between experimentalists and theorists. We look forward to your participation. Best regards, The Organizing Committee